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29189752
T-2 Toxin/HT-2 Toxin and Ochratoxin A ELISAs Development and In-House Validation in Food in Accordance with the Commission Regulation (EU) No 519/2014.
T-2 toxin/HT-2 toxin (T-2/HT-2) and ochratoxin A (OTA) are mycotoxins that can contaminate a variety of agricultural commodities. To protect consumers' health, indicative limits for T-2/HT-2 and maximum limits for OTA have been set by the European Commission, requiring food business operators and controlling agencies t...
[ 10613, 10063, 4117, 778, 4249, 7500, 6655, 9021, 97, 18710 ]
[ "Cacao", "Coffee", "Edible Grain", "Enzyme-Linked Immunosorbent Assay", "Food Contamination", "Government Regulation", "Limit of Detection", "Ochratoxins", "Reproducibility of Results", "T-2 Toxin" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 1, "J": 1, "L": 0, "M": 0, "N": 1, "Z": 0 }
16036476
Vision and self-rated health: longitudinal findings from an older Australian population.
PURPOSE: To assess temporal associations between vision and self-rated health.METHODS: We examined 3654 Australian residents (82.4% response) aged 49+ years in the Blue Mountains Eye Study, during 1992 to 1994, and re-examined 2334 in 1997 to 1999. Change in vision was defined if baseline and 5-year visual acuity (VA) ...
[ 133, 437, 1812, 2, 984, 1587, 3, 379, 35, 160, 1163, 6802, 914, 2827, 999, 14699 ]
[ "Aged", "Aging", "Cohort Studies", "Female", "Health Status", "Health Surveys", "Humans", "Longitudinal Studies", "Male", "Middle Aged", "New South Wales", "Self Disclosure", "Vision Disorders", "Vision, Ocular", "Visual Acuity", "Visually Impaired Persons" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 1, "G": 1, "H": 0, "I": 1, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 1 }
9046483
Aedes albopictus and Ae. triseriatus eggs survive waste tire processing.
Tires that were either crudely chopped or more finely processed into shreds contained viable eggs. Field-collected remnants of 2-3 chopped tires contained viable Aedes albopictus eggs. After shredding tires seeded with mosquito eggs, 34 (4.6%) of an estimated 746 Ae. albopictus eggs and 21 (2.7%) of an estimated 774 Ae...
[ 1717, 30, 6961, 5691 ]
[ "Aedes", "Animals", "Ovum", "Refuse Disposal" ]
{ "A": 1, "B": 1, "C": 0, "D": 0, "E": 0, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 0 }
22760895
Prognostic value of the six-minute walk test in end-stage renal disease life expectancy: a prospective cohort study.
OBJECTIVES: The six-minute walk test has been widely used to evaluate functional capacity and predict mortality in several populations. Thus, the aim of this study was to evaluate the prognostic value of the six-minute walk test for the life expectancy of end-stage renal disease patients.METHODS: Patients over 18 years...
[ 9, 5677, 1178, 983, 2, 3, 3030, 2124, 35, 160, 384, 397, 1737, 131, 5585 ]
[ "Adult", "Epidemiologic Methods", "Exercise Test", "Exercise Therapy", "Female", "Humans", "Kidney Failure, Chronic", "Life Expectancy", "Male", "Middle Aged", "Oxygen Consumption", "Prognosis", "Reference Values", "Time Factors", "Walking" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 1, "H": 0, "I": 1, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
24002822
Histamine synthesis is required for granule maturation in murine mast cells.
Mast cells are the major sources of histamine, which is released in response to immunological stimulations. The synthesis of histamine is catalyzed by histidine decarboxylase (HDC). Previous studies have shown that Hdc(-/-) mast cells exhibit aberrant granule morphology with severely decreased granule content. Here, we...
[ 30, 7875, 51, 4600, 1496, 1615, 2, 1499, 7631, 10688, 35, 10397, 36, 446, 447, 2424, 3162, 12309, 12310, 12311, 12312 ]
[ "Animals", "Cell Degranulation", "Cells, Cultured", "Chymases", "Coculture Techniques", "Cytoplasmic Granules", "Female", "Fibroblasts", "Histamine", "Histidine Decarboxylase", "Male", "Mast Cells", "Mice", "Mice, Inbred BALB C", "Mice, Inbred C57BL", "Mice, Knockout", "Receptors, G-...
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
30345538
PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology.
BACKGROUND: Striatal cyclic adenosine monophosphate activity modulates movement and is determined from the balance between its synthesis by adenylate cyclase 5 (ADCY5) and its degradation by phosphodiesterase 10A (PDE10A).OBJECTIVE: We assessed the integrity of striatocortical pathways, in vivo, in 2 genetic hyperkinet...
[ 5175, 3303, 3468, 1024, 2771, 3, 666, 5916, 1144, 6820, 9045, 9186 ]
[ "Adenylyl Cyclases", "Basal Ganglia", "Corpus Striatum", "Dopamine Plasma Membrane Transport Proteins", "Globus Pallidus", "Humans", "Mutation", "Neostriatum", "Neurons", "Parkinsonian Disorders", "Phosphoric Diester Hydrolases", "Substantia Nigra" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
1499690
Neuronal migration on laminin involves neuronal contact formation followed by nuclear movement inside a preformed process.
Neuronal migration was investigated in rodent cerebellum in vitro and in vivo. Time-lapse video recording showed that cultured neurons migrated on laminin by first extending neurites that formed contacts with other neurons. This was followed by movement of the cell nucleus inside the preformed process. No guidance cues...
[ 30, 236, 3708, 546, 51, 4364, 4245, 3076, 4, 6383, 36, 447, 2897, 3045, 3078, 1144, 43, 700, 7155 ]
[ "Animals", "Animals, Newborn", "Antibodies", "Cell Movement", "Cells, Cultured", "Cerebellum", "Embryo, Mammalian", "Glial Fibrillary Acidic Protein", "Immunohistochemistry", "Laminin", "Mice", "Mice, Inbred C57BL", "Mice, Inbred Strains", "Neurites", "Neurofilament Proteins", "Neurons...
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
31694968
False-Positive Results for Human Immunodeficiency Virus Type 1 Nucleic Acid Amplification Testing in Chimeric Antigen Receptor T Cell Therapy.
Chimeric antigen receptor (CAR) T cell immunotherapy has been a major advancement in cancer therapeutics. Reprogramming of T cells is achieved by using gammaretroviral or lentiviral vectors, which may interfere with human immunodeficiency virus type 1 (HIV-1) nucleic acid amplification testing (NAAT). Here, we describe...
[ 204, 133, 2, 420, 3314, 3, 13638, 35, 1550, 1037, 6278, 1047, 144, 1907 ]
[ "Adolescent", "Aged", "Female", "HIV Infections", "HIV-1", "Humans", "Immunotherapy, Adoptive", "Male", "Nucleic Acid Amplification Techniques", "RNA, Viral", "Receptors, Chimeric Antigen", "T-Lymphocytes", "Treatment Outcome", "Viral Load" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
25981221
Accuracy of simple plain radiographic signs and measures to diagnose acute scapholunate ligament injuries of the wrist.
OBJECTIVE: To determine the accuracy of common radiological indices for diagnosing ruptures of the scapholunate (SL) ligament, the most relevant soft tissue injury of the wrist.METHODS: This was a prospective diagnostic accuracy study with independent verification of index test findings by a reference standard (wrist a...
[ 204, 9, 133, 2, 3, 6404, 35, 160, 3328, 1269, 111, 189, 97, 98, 6518, 4637, 27 ]
[ "Adolescent", "Adult", "Aged", "Female", "Humans", "Ligaments, Articular", "Male", "Middle Aged", "Observer Variation", "Predictive Value of Tests", "Prospective Studies", "Radiography", "Reproducibility of Results", "Sensitivity and Specificity", "Wrist Injuries", "Wrist Joint", "Yo...
{ "A": 1, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
25081563
Design, synthesis, and biological activities of novel azole-bonded â-hydroxypropyl oxime O-ethers.
The synthesis and biological effects of 15 novel azole-bonded â-hydroxypropyl oxime O-ethers have been described. In this synthesis, the oximation of aromatic ketones followed by an O-alkylation reaction with epichlorohydrin and/or epibromohydrin led to the corresponding O-oxime ether adducts. Subsequently, the attaine...
[ 728, 15111, 819, 2230, 1460, 2797, 716, 1911, 607, 2409, 991 ]
[ "Antifungal Agents", "Azoles", "Bacterial Proteins", "Catalytic Domain", "Drug Design", "Ethers", "Models, Molecular", "Molecular Docking Simulation", "Molecular Structure", "Oximes", "Structure-Activity Relationship" ]
{ "A": 0, "B": 0, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
31775035
Revealing Functional Crosstalk between Distinct Bioprocesses through Reciprocal Functional Tests of Genetically Interacting Genes.
To systematically explore the genes mediating functional crosstalk between metazoan biological processes, we apply comparative genetic interaction (GI) mapping in Saccharomyces cerevisiae and Caenorhabditis elegans to generate an inter-bioprocess network consisting of 178 C. elegans GIs. The GI network spans six annota...
[ 30, 1261, 3174, 9170, 662, 3 ]
[ "Animals", "Biological Transport", "Caenorhabditis elegans", "Caenorhabditis elegans Proteins", "Endosomes", "Humans" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
11783641
Volatilization of toxaphene from Lakes Michigan and Superior.
The pesticide toxaphene was used extensively on cotton in the southern United States until its use was restricted in 1982. It was previously reported that the upper Great Lakes have received toxaphene by gas absorption following long-range transport from the south and are currently saturated with respect to toxaphene. ...
[ 247, 248, 15425, 3974, 653, 20591, 6967 ]
[ "Environmental Monitoring", "Gases", "Great Lakes Region", "Insecticides", "Temperature", "Toxaphene", "Volatilization" ]
{ "A": 0, "B": 0, "C": 0, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 1 }
26309288
Effects of Planting Date and Barley Variety on Russian Wheat Aphid (Hemiptera: Aphididae) Populations in Colorado, Kansas, and Nebraska.
The Russian wheat aphid, Diuraphis noxia (Kurdjumov) (Hemiptera: Aphididae), is an important pest in the western Great Plains of the United States, where it causes hundreds of millions of dollars of losses to barley and wheat production through reduced yields. Experiments to evaluate the effect of early planting and re...
[ 30, 3126, 7658, 3129, 5542, 9903, 14335, 14909, 2519, 23 ]
[ "Animals", "Aphids", "Colorado", "Herbivory", "Hordeum", "Insect Control", "Kansas", "Nebraska", "Population Dynamics", "Seasons" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 0, "F": 1, "G": 1, "H": 0, "I": 1, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 1 }
21422359
Racial disparities in survival after lung transplantation.
CONTEXT: Racial disparities have not been comprehensively evaluated among recipients of lung transplantation.OBJECTIVES: To describe the association between race and lung transplant survival and to determine whether racial disparities have changed in the modern (2001-2009) compared with the historical (1987-2000) trans...
[ 9, 1196, 3658, 1812, 218, 2, 163, 2861, 4260, 3, 5282, 232, 35, 160, 695, 1814, 598, 1889, 542, 144, 132, 950 ]
[ "Adult", "African Americans", "Cause of Death", "Cohort Studies", "European Continental Ancestry Group", "Female", "Follow-Up Studies", "Health Status Disparities", "Healthcare Disparities", "Humans", "Kaplan-Meier Estimate", "Lung Transplantation", "Male", "Middle Aged", "Postoperative ...
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 1, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 1 }
26044185
Androgen and oestrogen modulation by D-aspartate in rat epididymis.
Testosterone (T) synthesised in Leydig cells enters the epididymis and may there be converted into dihydrotestosterone (DHT) by 5á-reductase (5á-red) or into 17â-oestradiol (E2) by P450 aromatase (P450-aro). D-aspartate (D-Asp) is known to induce T synthesis in the testis. In this study, we investigated the effects of ...
[ 7950, 30, 4378, 16988, 12136, 5800, 765, 3264, 35, 43, 9370, 4595 ]
[ "3-Oxo-5-alpha-Steroid 4-Dehydrogenase", "Animals", "Aromatase", "D-Aspartic Acid", "Dihydrotestosterone", "Epididymis", "Estradiol", "Estrogens", "Male", "Rats", "Receptors, Androgen", "Testosterone" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 0, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
31893414
Differences in Muscle O2
The aim of this study was to compare muscle O2 dynamics during exercise between aerobic capacity-matched overweight and normal-weight adults. Overweight women (OW, n = 9) and normal-weight women (NW, n = 14) performed graded treadmill exercise until exhaustion. Muscle O2 saturation (SmO2) and relative changes from rest...
[ 9, 1177, 1178, 2, 1179, 3, 60, 2150, 384 ]
[ "Adult", "Exercise", "Exercise Test", "Female", "Hemoglobins", "Humans", "Muscle, Skeletal", "Overweight", "Oxygen Consumption" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 1, "J": 0, "L": 0, "M": 1, "N": 0, "Z": 0 }
28456770
Safety and efficacy of intravenous cyclophosphamide pulse therapy in therapy refractory Crohn's disease patients.
A major challenge in the management of persistently active Crohn's disease patient's refractory to treatment regimen following the current guidelines is the induction of remission, which is a prerequisite for subsequent maintenance therapy. The aim of this study was to evaluate both the clinical and endoscopic benefit ...
[ 9701, 9, 2873, 4009, 2398, 1524, 3637, 2, 3, 770, 35, 160, 8910, 144 ]
[ "Administration, Intravenous", "Adult", "C-Reactive Protein", "Crohn Disease", "Cyclophosphamide", "Drug Resistance", "Endoscopy, Gastrointestinal", "Female", "Humans", "Immunosuppressive Agents", "Male", "Middle Aged", "Pulse Therapy, Drug", "Treatment Outcome" ]
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
31653755
Current trends in the acute treatment of ischemic stroke: analysis from the Paul Coverdell National Acute Stroke Program.
BACKGROUND: The intra-arterial treatment (IAT) of acute ischemic stroke (AIS) is now evidence-based and given the highest level of recommendation among eligible patients. Using a multi-state stroke registry, we studied the trend in IAT among patients with AIS over 11 years and its impact on the utilization of intraveno...
[ 133, 974, 2, 2260, 3, 2578, 138, 11326, 1026, 35, 160, 7750, 2433, 142, 2263, 144 ]
[ "Aged", "Brain Ischemia", "Female", "Fibrinolytic Agents", "Humans", "Infusions, Intra-Arterial", "Infusions, Intravenous", "Injections, Intra-Arterial", "Injections, Intravenous", "Male", "Middle Aged", "Quality Improvement", "Registries", "Stroke", "Thrombolytic Therapy", "Treatment ...
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 1, "L": 0, "M": 1, "N": 1, "Z": 0 }
23834066
Capsule endoscopy in a network cooperation: assessment of the experience in 822 patients.
INTRODUCTION: Capsule endoscopy (CE) is firmly established as a standard procedure in the diagnostic algorithm of occult or obscure gastrointestinal bleeding and Crohn's disease. Despite its excellent diagnostic yield, missing expertise, reading time and financial expenditure limit an area-wide availability. A multicen...
[ 3397, 204, 9, 133, 310, 14171, 21827, 5459, 2095, 7966, 4009, 15246, 2, 6323, 2390, 3474, 3, 17269, 5203, 15570, 35, 160, 11162, 3548, 27 ]
[ "Abdominal Pain", "Adolescent", "Adult", "Aged", "Aged, 80 and over", "Angiodysplasia", "Capsule Endoscopes", "Capsule Endoscopy", "Cooperative Behavior", "Cost Savings", "Crohn Disease", "Duodenal Neoplasms", "Female", "Gastrointestinal Diseases", "Gastrointestinal Hemorrhage", "Gastr...
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 1, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 1, "N": 1, "Z": 0 }
31742831
Clinical application of Web Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo): Patterns of blood sampling and patient characteristics among clinician users.
BACKGROUND: Use of population pharmacokinetics (PopPK) to facilitate PK-informed prophylaxis in clinical practice has gained momentum among haemophilia providers due to the accessibility of tools such as the Web Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) and availability of extended half-life...
[ 204, 9, 133, 310, 7302, 104, 105, 134, 2490, 4392, 3, 14, 2209, 160, 3591, 27 ]
[ "Adolescent", "Adult", "Aged", "Aged, 80 and over", "Blood Specimen Collection", "Child", "Child, Preschool", "Dose-Response Relationship, Drug", "Factor VIII", "Hemophilia A", "Humans", "Infant", "Internet", "Middle Aged", "Physicians", "Young Adult" ]
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 1, "N": 1, "Z": 0 }
11536196
Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques.
The tumor necrosis factor (TNF)-alpha converting enzyme (TACE) can cleave the cell-surface ectodomain of the amyloid-beta precursor protein (APP), thus decreasing the generation of amyloid-beta (Abeta) by cultured non-neuronal cells. While the amyloidogenic processing of APP in neurons is linked to the pathogenesis of ...
[ 6917, 6918, 409, 711, 206, 349, 3, 3840, 1144, 6919, 1737, 465, 1284 ]
[ "ADAM Proteins", "ADAM17 Protein", "Alzheimer Disease", "Amyloid beta-Peptides", "Brain", "Cell Extracts", "Humans", "Metalloendopeptidases", "Neurons", "Plaque, Amyloid", "Reference Values", "Tissue Distribution", "Tumor Cells, Cultured" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 1, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
22995465
Raman spectroscopic study of the hydroxy-phosphate mineral plumbogummite PbAl₃(PO₄)₂(OH,H₂O)₆.
Plumbogummite PbAl(3)(PO(4))(2)(OH,H(2)O)(6) is a mineral of environmental significance and is a member of the alunite-jarosite supergroup. The molecular structure of the mineral has been investigated by Raman spectroscopy. The spectra of different plumbogummite specimens differ although there are many common features....
[ 744, 4373, 5151, 2387, 2594, 473, 14159, 3609, 701 ]
[ "Aluminum", "Aluminum Compounds", "Ferric Compounds", "Lead", "Minerals", "Phosphates", "Potassium Compounds", "Spectrum Analysis, Raman", "Sulfates" ]
{ "A": 0, "B": 0, "C": 0, "D": 1, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
11967007
Gene expression profile of renal proximal tubules regulated by proteinuria.
BACKGROUND: Proximal tubules activated by reabsorption of protein are thought to play significant roles in the progression of kidney diseases. Thus, identification of genes related to proteinuria should provide insights into the pathological process of tubulointerstitial fibrosis.METHOD: Gene expression profiles were c...
[ 28, 30, 2814, 10530, 439, 2672, 613, 2, 1131, 3, 7019, 3921, 35, 285, 36, 447, 37, 5707, 451, 3042, 452, 1047, 2444 ]
[ "Amino Acid Sequence", "Animals", "Antigens, Ly", "Avian Proteins", "Base Sequence", "Chromosome Mapping", "Disease Models, Animal", "Female", "Gene Expression Profiling", "Humans", "Kidney Tubules, Proximal", "Lipoproteins", "Male", "Membrane Proteins", "Mice", "Mice, Inbred C57BL", ...
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
9079716
Characterization of recombinant human lactoferrin secreted in milk of transgenic mice.
Human lactoferrin (hLF) is an iron-binding protein involved in host defense against infection and severe inflammation. Transgenic mice were produced harboring either hLF cDNA or genomic hLF sequences fused to regulatory elements of the bovine alphaS1 casein gene. Recombinant hLF expressed in the milk of transgenic mice...
[ 30, 424, 625, 2475, 777, 6243, 3, 2654, 12545, 36, 500, 2222, 1066, 506 ]
[ "Animals", "Cattle", "Chromatography, Gel", "DNA, Complementary", "Electrophoresis, Polyacrylamide Gel", "Glycosylation", "Humans", "Iron", "Lactoferrin", "Mice", "Mice, Transgenic", "Milk", "Radioimmunoassay", "Recombinant Proteins" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 1, "L": 0, "M": 0, "N": 0, "Z": 0 }
7125385
Hyperbaric medicine: state of the art, 1979.
An attempt has been made to determine the clinical usage of hyperbaric oxygen therapy at 83 North American hyperbaric treatment centers from 1971 to 1978. Questions were asked about the conditions or diseases treated, yearly case load for each condition, location of functional hyperbaric chambers, types of chambers use...
[ 974, 992, 15480, 7852, 13082, 10877, 15481, 3, 10878, 2003, 7979 ]
[ "Brain Ischemia", "Burns", "Carbon Monoxide Poisoning", "Craniocerebral Trauma", "Decompression Sickness", "Embolism, Air", "Gas Gangrene", "Humans", "Hyperbaric Oxygenation", "Osteomyelitis", "Osteoradionecrosis" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
9423858
Role of tumor necrosis factor alpha in gnotobiotic mice infected with an Escherichia coli O157:H7 strain.
Gnotobiotic mice inoculated with an enterohemorrhagic Escherichia coli (EHEC) O157:H7 strain developed a flaccid paresis, usually culminating in death. The bacteria colonized feces at 10(9) to 10(10) CFU per g (inoculum size: 2.0 x 10(9) CFU/mouse), and Shiga-like toxins (SLTs) were detected in the feces. A microscopic...
[ 30, 2215, 206, 2875, 3716, 2358, 1171, 5587, 157, 2, 4428, 8164, 4389, 1837, 989, 35, 36, 1806, 852, 15619, 314, 875 ]
[ "Animals", "Bacterial Toxins", "Brain", "Colon", "Colony Count, Microbial", "Edema", "Escherichia coli Infections", "Escherichia coli O157", "Feces", "Female", "Germ-Free Life", "Guanidines", "Interleukin-1", "Interleukin-6", "Kidney", "Male", "Mice", "Mice, Inbred ICR", "Proteas...
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
30813999
Artificial Lysosomal Platform to Study Nanoparticle Long-term Stability.
Nanoparticles (NPs) possess unique properties useful for designing specific functionalities for biomedi- cal applications. A prerequisite of a safe-by-design and effective use in any biomedical application is to study NP-cell interactions to gain a better understanding of cellular consequences upon exposure. Cellular u...
[ 3982, 816, 81, 5394 ]
[ "Gold", "Lysosomes", "Nanoparticles", "Silicon Dioxide" ]
{ "A": 1, "B": 0, "C": 0, "D": 1, "E": 0, "F": 0, "G": 0, "H": 0, "I": 0, "J": 1, "L": 0, "M": 0, "N": 0, "Z": 0 }
26302091
Inhibitory effect of natural organic matter or other background constituents on photocatalytic advanced oxidation processes: Mechanistic model development and validation.
The ability of reactive oxygen species (ROS) to interact with priority pollutants is crucial for efficient water treatment by photocatalytic advanced oxidation processes (AOPs). However, background compounds in water such as natural organic matter (NOM) can significantly hinder targeted reactions and removal efficiency...
[ 988, 855, 953, 3809, 364, 326 ]
[ "Catalysis", "Hydrogen Peroxide", "Oxidation-Reduction", "Photolysis", "Reactive Oxygen Species", "Water Pollutants, Chemical" ]
{ "A": 0, "B": 0, "C": 0, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
25550532
The anti-hypertensive drug prazosin induces apoptosis in the medullary thyroid carcinoma cell line TT.
BACKGROUND/AIM: Medullary thyroid carcinoma (MTC) is a tumor associated with poor prognosis since it exhibits high resistance against conventional cancer therapy. Recent studies have shown that quinazolines exhibit a pro-apoptotic effect on malignant cells. The aim of the present study was to elucidate whether MTC cell...
[ 521, 71, 193, 12946, 389, 2624, 3, 525, 12947, 3292 ]
[ "Antihypertensive Agents", "Antineoplastic Agents", "Apoptosis", "Carcinoma, Medullary", "Cell Line, Tumor", "Drug Screening Assays, Antitumor", "Humans", "Prazosin", "Receptors, Adrenergic, alpha-1", "Thyroid Neoplasms" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
22738004
Teaching the teachers: faculty preparedness and evaluation of a retreat in screening, brief intervention, and referral to treatment.
Effective clinical faculty are essential for disseminating substance abuse screening, brief intervention, and referral to treatment (SBIRT). The authors developed an 8-hour SBIRT training for internal medicine faculty preceptors. Trainers conducted SBIRT lectures and small-group communication practice sessions. The aut...
[ 5303, 876, 878, 12713, 2, 3, 7301, 35, 939, 4800, 882, 11203 ]
[ "Alcohol-Related Disorders", "Attitude of Health Personnel", "Clinical Competence", "Faculty, Medical", "Female", "Humans", "Internal Medicine", "Male", "Program Development", "Psychotherapy, Brief", "Referral and Consultation", "Substance Abuse Detection" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 1, "G": 0, "H": 1, "I": 1, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
16035664
[Short account of the history of thyroid surgery].
Historical writings have described abnormalities of the thyroid gland for more than 3500 years. The relationship between the thyroid gland and goiter has been unknown until the XX century. Originally, what we know today as goiter was described as bronchocele. It was Wharton who in 1656 named the gland "thyroid", not be...
[ 1613, 6958, 6959, 2514, 2515, 2473, 1819, 1432, 1442, 6960, 3, 3452 ]
[ "Europe", "Goiter", "History, 15th Century", "History, 16th Century", "History, 17th Century", "History, 18th Century", "History, 19th Century", "History, 20th Century", "History, Ancient", "History, Medieval", "Humans", "Thyroidectomy" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 1 }
23563525
Disulfide-bond scanning reveals assembly state and â-strand tilt angle of the PFO â-barrel.
Perfringolysin O (PFO), a bacterial cholesterol-dependent cytolysin, binds a mammalian cell membrane, oligomerizes into a circular prepore complex (PPC) and forms a 250-? transmembrane â-barrel pore in the cell membrane. Each PFO monomer has two sets of three short á-helices that unfold and ultimately refold into two t...
[ 2215, 283, 1085, 5399, 74, 1278, 4304, 352, 1324, 1415, 1399, 666, 372, 718, 653, 4561 ]
[ "Bacterial Toxins", "Cell Membrane", "Cholesterol", "Clostridium perfringens", "Cross-Linking Reagents", "Dimerization", "Disulfides", "Escherichia coli", "Hemolysin Proteins", "Liposomes", "Molecular Conformation", "Mutation", "Protein Binding", "Protein Structure, Secondary", "Temperat...
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 1, "L": 0, "M": 0, "N": 1, "Z": 0 }
3417465
Effect of peak flow information on patterns of self-care in adult asthma.
Self-care is an important issue in the management of adults with asthma. Little is known about the specific strategies used by people with asthma to control symptoms and abort asthma attacks. The purpose of this study was to identify self-care strategies used to control asthma symptoms and to determine the effect of pe...
[ 475, 9, 3916, 4317, 2, 3, 35, 10797, 1784, 1137 ]
[ "Adaptation, Psychological", "Adult", "Asthma", "Bronchodilator Agents", "Female", "Humans", "Male", "Peak Expiratory Flow Rate", "Self Care", "Theophylline" ]
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 1, "G": 1, "H": 0, "I": 1, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
17643694
Intraobserver and interobserver consistency for grading esophagitis with narrow-band imaging.
BACKGROUND: Narrow-band imaging (NBI) is a novel, noninvasive optical technique that adjusts reflected light to enhance the contrast between the esophageal mucosa and the gastric mucosa. Whether the use of this optical technique may increase consistency in describing the presence and severity of mucosal breaks remains ...
[ 3544, 3545, 3546, 1763, 3, 3547, 3328, 3548 ]
[ "Esophagitis", "Esophagoscopy", "Esophagus", "Gastric Mucosa", "Humans", "Mucous Membrane", "Observer Variation", "Video Recording" ]
{ "A": 1, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 1, "Z": 0 }
6716461
A section press and low elemental support for enhanced preparation of freeze-dried cryosections.
A press- and specimen holder system is described, whereby thin, freeze-dried cryosections can be obtained more conveniently and with greater protection against contamination and harmful temperature fluctuations. The use of a grid and retainer assembly as the basic working unit, greatly facilitates low temperature work ...
[ 30, 2687, 3, 43, 1116 ]
[ "Animals", "Freeze Drying", "Humans", "Rats", "Specimen Handling" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
22436888
Structural features of â-(1?4)-D-galactomannans of plant origin as a probe for â-(1?4)-mannanase polymeric substrate specificity.
Statistical modeling was applied for describing structural features of â-(1?4)-D-galactomannans. According to the model suggested theoretical ratios of limiting degrees of locust bean, tara gum and guar gum galactomannan conversions by two â-(1?4)-mannanases of different origin (Myceliophthora thermophila and Trichoder...
[ 1660, 2705, 252, 2706, 758, 2707, 2708 ]
[ "Hydrolysis", "Mannans", "Plants", "Sordariales", "Substrate Specificity", "Trichoderma", "beta-Mannosidase" ]
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
7704612
Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra.
The observation that Parkinson's disease (PD) is associated with locus coeruleus (LC) noradrenergic neuronal degeneration suggests that the LC noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (SN) dopaminergic neurons in Parkinson's disease. The...
[ 30, 439, 1924, 4, 2496, 8272, 15231, 36, 446, 37, 1753, 3543, 452, 9186, 9187 ]
[ "Animals", "Base Sequence", "Dopamine", "Immunohistochemistry", "In Situ Hybridization", "Locus Coeruleus", "MPTP Poisoning", "Mice", "Mice, Inbred BALB C", "Molecular Sequence Data", "Norepinephrine", "Oxidopamine", "RNA, Messenger", "Substantia Nigra", "Tyrosine 3-Monooxygenase" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
24814586
Unemployment under the flex job scheme increases the risk of permanent social security benefits.
INTRODUCTION: In Denmark, a flex job scheme was introduced in 1998 in the expectation that more people could remain in the workforce despite a reduced working capacity. The aim of this study was to characterise the group that did not obtain a flex job after having been included in the flex job scheme.MATERIAL AND METHO...
[ 2429, 3, 3289, 10564 ]
[ "Denmark", "Humans", "Social Security", "Unemployment" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 0, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 1 }
7046812
A study of physician attitude on biofeedback.
A study of physician attitudes on biofeedback was conducted among members of the Harris County Medical Society, Harris County, Texas. The sample was drawn to match the proportionate representation in the society by speciality. Findings indicated that over 62% of the respondents had little knowledge of biofeedback, over...
[ 876, 7765, 2267, 7465, 5482, 3, 1312, 5723, 2909, 14559, 15766, 882, 6235, 5724 ]
[ "Attitude of Health Personnel", "Biofeedback, Psychology", "Epilepsy", "Fecal Incontinence", "Headache", "Humans", "Hypertension", "Medicine", "Neuromuscular Diseases", "Pain, Intractable", "Raynaud Disease", "Referral and Consultation", "Relaxation Therapy", "Specialization" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 1, "G": 0, "H": 1, "I": 0, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 0 }
18753667
Occupation-related differences in the prevalence of metabolic syndrome.
OBJECTIVE: To investigate the prevalence of metabolic syndrome in the Spanish working population and determine how the prevalence varies according to occupation and sex.RESEARCH DESIGN AND METHODS: This was a cross-sectional study of 259,014 workers (mean age 36.4 years, range [16-74]; 72.9% male) who underwent a routi...
[ 736, 1718, 862, 2013, 2, 3, 3144, 35, 3992, 2769, 1274, 1721, 1347 ]
[ "Blood Glucose", "Body Size", "Body Weight", "Educational Status", "Female", "Humans", "Income", "Male", "Metabolic Syndrome", "Occupations", "Prevalence", "Sex Characteristics", "Spain" ]
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 1 }
9361906
Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice.
The subchronic toxicity of ISIS 2302 and ISIS 3082, phosphorothioate oligonucleotides with antisense activity against human and murine ICAM-1 mRNA, respectively, was investigated in CD-1 mice. ISIS 2302 is currently in clinical trials as an anti-inflammatory agent. Because of the differences in mRNA sequence targets be...
[ 30, 2073, 7783, 19678, 3417, 2, 1098, 989, 427, 814, 35, 36, 8352, 8860, 870, 21152, 122 ]
[ "Animals", "Anti-Inflammatory Agents, Non-Steroidal", "Blood Cells", "Clinical Chemistry Tests", "Drug Evaluation, Preclinical", "Female", "Hyperplasia", "Kidney", "Liver", "Lung", "Male", "Mice", "Oligodeoxyribonucleotides, Antisense", "Oligonucleotides, Antisense", "Organ Size", "Pho...
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
29729381
STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ.
Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in colorectal carcinoma (CRC) remains poorly understood. In present study, we aim to investigate the role of lncRNA LINC00174 in CRC carcinogenesis. We observed that increased expression...
[ 389, 1262, 4526, 1657, 2439, 1285, 3, 2121, 5282, 548, 397, 1287, 3255, 14186, 2792, 2677, 2444 ]
[ "Cell Line, Tumor", "Colorectal Neoplasms", "CpG Islands", "DNA Methylation", "Disease Progression", "Gene Expression Regulation, Neoplastic", "Humans", "Intracellular Signaling Peptides and Proteins", "Kaplan-Meier Estimate", "MicroRNAs", "Prognosis", "RNA Interference", "RNA, Long Noncodin...
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 0 }
2948636
Biological studies on the main fractions of hematoporphyrin derivative.
The four main fractions of hematoporphyrin derivative were separated by high-pressure liquid chromatography. Each fraction was studied with respect to photosensitizing capabilities, fluorescence, and tumor tissue uptake in mice bearing EMT-6 tumors. Animals received i.p. injections of 10 mg/kg of each fraction, and 24 ...
[ 30, 626, 13089, 9041, 36, 1115, 3951, 7861 ]
[ "Animals", "Chromatography, High Pressure Liquid", "Hematoporphyrin Derivative", "Hematoporphyrins", "Mice", "Microscopy, Fluorescence", "Neoplasms, Experimental", "Radiation-Sensitizing Agents" ]
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
18042732
2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.
Long and short QT syndromes associated with loss and gain of human ether-a-go-go-related gene (hERG) channel activity, respectively, can cause life-threatening arrhythmias. As such, modulation of hERG channel activity is an important consideration in the development of all new therapeutic agents. In the present study, ...
[ 1923, 30, 1703, 4058, 1051, 4062, 2711, 134, 1141, 15350, 2505, 3, 1244, 7830, 305, 35, 36, 1857, 716, 607, 619, 5832, 9717, 243, 372, 718, 373, 772, 621 ]
[ "Action Potentials", "Animals", "Binding Sites", "CHO Cells", "Cricetinae", "Cricetulus", "Data Interpretation, Statistical", "Dose-Response Relationship, Drug", "Electric Conductivity", "Ether-A-Go-Go Potassium Channels", "Heart Ventricles", "Humans", "Hydrophobic and Hydrophilic Interactio...
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 1, "Z": 0 }
7933172
The fate of the adult exstrophy patient.
Between 1968 and 1993, 101 patients with bladder exstrophy or incontinent epispadias underwent surgery at our hospital. The standard procedure was ureterosigmoidostomy and additional genital reconstruction. Of the 56 patients who have reached adulthood 45 could be interviewed regarding social integration, sexuality and...
[ 204, 9, 19167, 2, 15477, 3858, 3, 2465, 35, 695, 144, 5949 ]
[ "Adolescent", "Adult", "Bladder Exstrophy", "Female", "Genitalia, Female", "Genitalia, Male", "Humans", "Infertility, Male", "Male", "Postoperative Complications", "Treatment Outcome", "Urinary Diversion" ]
{ "A": 1, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
29401052
Psychiatric Aspects of Extreme Sports: Three Case Studies.
Extreme sports, defined as sporting or adventure activities involving a high degree of risk, have boomed since the 1990s. These types of sports attract men and women who can experience a life-affirming transcendence or "flow" as they participate in dangerous activities. Extreme sports also may attract people with a gen...
[ 15078, 2, 3, 6890, 35, 3486, 12266, 1782, 16324, 11234, 1580, 1405 ]
[ "Dangerous Behavior", "Female", "Humans", "Impulsive Behavior", "Male", "Motivation", "Physician's Role", "Primary Health Care", "Psychology, Sports", "Recreation", "Risk-Taking", "Sports" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 0, "F": 1, "G": 0, "H": 0, "I": 1, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 0 }
8041806
Structure-specific binding and photosensitized cleavage of branched DNA three-way junction complexes by cationic porphyrins.
The interactions of cationic porphyrins with DNA oligonucleotides that form branched, three-way junction complexes (TWJ) were investigated using native gel electrophoresis, absorption spectroscopy and photochemical probing using DNA sequencing techniques. Meso-tetra(para-N- trimethylaniliniumyl)porphine (TMAP), meso-te...
[ 28, 1703, 1226, 34, 716, 37, 607, 3813, 431, 432 ]
[ "Amino Acid Sequence", "Binding Sites", "DNA", "In Vitro Techniques", "Models, Molecular", "Molecular Sequence Data", "Molecular Structure", "Photochemistry", "Photosensitizing Agents", "Porphyrins" ]
{ "A": 0, "B": 0, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
29748912
Investigating changes in mortality attributable to heat and cold in Stockholm, Sweden.
Projections of temperature-related mortality rely upon exposure-response relationships using recent data. Analyzing long historical data and trends may extend knowledge of past and present impacts that may provide additional insight and improve future scenarios. We collected daily mean temperatures and daily all-cause ...
[ 886, 1690, 854, 3, 2040, 348, 653 ]
[ "Cold Temperature", "Forecasting", "Hot Temperature", "Humans", "Mortality", "Sweden", "Temperature" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 1, "F": 0, "G": 1, "H": 0, "I": 1, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 1 }
8311207
Predictable nitrous oxide uptake enables simple oxygen uptake monitoring during low flow anaesthesia.
The uptake rate of oxygen and nitrous oxide were studied during low flow anaesthesia with enflurane or isoflurane in nitrous oxide with either spontaneous or controlled ventilation. The excess gas flow and composition were analysed. The nitrous oxide uptake rate was in agreement with Severinghaus' formula VN20 1000.t-0...
[ 9, 2803, 16073, 2, 3, 2805, 35, 1542, 2806, 384, 152 ]
[ "Adult", "Anesthesia, Inhalation", "Enflurane", "Female", "Humans", "Isoflurane", "Male", "Models, Biological", "Nitrous Oxide", "Oxygen Consumption", "Respiration, Artificial" ]
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 0, "Z": 0 }
15548644
The subcellular organization of cortactin in hippocampus.
Spines may undergo rapid, activity-dependent changes in shape and size, reflecting reorganization of the actin cytoskeleton. This remodeling is implicated in development and also in the late phase of long-term potentiation. However, the cellular mechanisms that convert activity into morphological change remain poorly u...
[ 281, 30, 17117, 9664, 241, 4, 35, 8688, 428, 286, 1144, 43, 69 ]
[ "Actins", "Animals", "Cortactin", "Dendritic Spines", "Hippocampus", "Immunohistochemistry", "Male", "Microfilament Proteins", "Microscopy, Confocal", "Microscopy, Electron", "Neurons", "Rats", "Rats, Sprague-Dawley" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 0, "H": 1, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
10691966
N-Linked glycans of proteins from mitral valves of normal pigs and pigs affected by endocardiosis.
Endocardiosis, a degenerative and dystrophic process affecting cardiac valves and described in many mammalian species, is characterized by the accumulation of glycosaminoglycans, in particular hyaluronic acid, in the extracellular matrix. The glycoprotein patterns of pig mitral valves in normal animals and animals affe...
[ 30, 7392, 3444, 3447, 4922, 630, 572 ]
[ "Animals", "Carbohydrate Sequence", "Endocarditis", "Mitral Valve", "Polysaccharides", "Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization", "Swine" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
9564229
[The current status of organ transplantation: the role of xenotransplantation?].
In the last few years, transplantation was an area of intense research activity. However, there is a worldwide shortage of donor organs for clinical transplantations. Currently, interest in xenotransplantation research is growing not only because of the increased demand for organs but also because of advances in molecu...
[ 30, 7366, 2109, 3194, 3, 4644, 6474, 4824, 4412, 949, 2742, 14795, 6783 ]
[ "Animals", "Genetic Techniques", "Graft Rejection", "Graft Survival", "Humans", "Immunologic Techniques", "Molecular Biology", "Organ Transplantation", "Research", "Tissue Donors", "Tissue and Organ Procurement", "Transplantation Immunology", "Transplantation, Heterologous" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 1, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
20843975
Menarchal timing in type 1 diabetes through the last 4 decades.
OBJECTIVE: We sought to examine whether age at menarche has changed over the past 4 decades by comparing age at menarche by year of diagnosis with type 1 diabetes.RESEARCH DESIGN AND METHODS: This work consisted of a cross-sectional study of age at menarche in two cohorts: adolescents (ages 11-24 years, n = 228) and ad...
[ 204, 9, 104, 12, 3635, 2, 3, 9869, 160, 27 ]
[ "Adolescent", "Adult", "Child", "Cross-Sectional Studies", "Diabetes Mellitus, Type 1", "Female", "Humans", "Menarche", "Middle Aged", "Young Adult" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
6706963
The accumulation of malonyldialdehyde, a product of fatty acid peroxidation, can disturb aminophospholipid organization in the membrane bilayer of human erythrocytes.
The distribution of phospholipids across erythrocyte membrane bilayer is asymmetrical. The present study reports the effect of malonyldialdehyde (MDA), a product of fatty acid peroxidation, on the organization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in human erythrocytes using a nonpermeable bee ve...
[ 507, 851, 3, 855, 1122, 14670, 3105, 9897, 5149, 2590, 5993, 5994 ]
[ "Antioxidants", "Erythrocyte Membrane", "Humans", "Hydrogen Peroxide", "Lipid Bilayers", "Malonates", "Malondialdehyde", "Membrane Lipids", "Phosphatidylethanolamines", "Phosphatidylserines", "Phospholipases A", "Phospholipases A2" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 0, "F": 0, "G": 0, "H": 0, "I": 0, "J": 1, "L": 0, "M": 0, "N": 0, "Z": 0 }
10440490
Effects of monensin feeding during development on female rats and their offspring.
Monensin, a growth-promoting agent and coccidiostat used in veterinary medicine, was studied in terms of its effects on the development of female rats and their offspring when added to the diet. Young female rats received 100 or 300 ppm monensin mixed with powdered chow diet until adulthood, when they were mated and th...
[ 30, 1104, 862, 5695, 134, 2, 6874, 35, 683, 4957, 20, 43, 245, 417 ]
[ "Animals", "Behavior, Animal", "Body Weight", "Coccidiostats", "Dose-Response Relationship, Drug", "Female", "Incisor", "Male", "Maternal-Fetal Exchange", "Monensin", "Pregnancy", "Rats", "Rats, Wistar", "Sex Factors" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 1, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 0 }
23644712
Recurrence of mediastinal node cancer after lobe-specific systematic nodal dissection for non-small-cell lung cancer.
OBJECTIVES: The standard surgical treatment for patients with non-small-cell lung cancer (NSCLC) is lobectomy with systematic nodal dissection (SND). Lobe-specific patterns of nodal metastases have been recognized, and lobe-specific SND (L-SND) has been reported. We performed L-SND depending on patient-related factors,...
[ 9, 133, 310, 1963, 2407, 2, 3, 5282, 159, 1183, 4661, 35, 923, 160, 6585, 1237 ]
[ "Adult", "Aged", "Aged, 80 and over", "Carcinoma, Non-Small-Cell Lung", "Disease-Free Survival", "Female", "Humans", "Kaplan-Meier Estimate", "Lung Neoplasms", "Lymph Node Excision", "Lymph Nodes", "Male", "Mediastinal Neoplasms", "Middle Aged", "Pneumonectomy", "Recurrence" ]
{ "A": 1, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
2755124
Purification and characterization of a heat- and acid-stable progestin binding protein of rat lung.
We report on the purification and characterization of a heat- and acid-stable progestin binding protein of rat lung cytosol, the binding behaviour and capacity of which have already been described by us. Using heat treatment, fractionated acetone precipitation, DEAE, HAP and Sephadex G-100 chromatography, the protein w...
[ 30, 1480, 627, 2417, 777, 305, 814, 36, 1532, 17733, 3358, 1722, 4757 ]
[ "Animals", "Chemical Precipitation", "Chromatography, Ion Exchange", "Cytosol", "Electrophoresis, Polyacrylamide Gel", "Kinetics", "Lung", "Mice", "Molecular Weight", "Progesterone-Binding Globulin", "Receptors, Progesterone", "Species Specificity", "Ultracentrifugation" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
22674502
Comparative secretome analysis of human bone marrow-derived mesenchymal stem cells during osteogenesis.
Osteogenesis is a tightly regulated process that involves coordinated extracellular signals from autocrine and paracrine loops. Secretory proteins during osteogenesis can inhibit cell proliferation and activate cell differentiation toward mature osteoblasts, which are characterized by mineralization. In this study, we ...
[ 864, 3005, 614, 3, 618, 1951, 3989, 3990, 5108 ]
[ "Bone Marrow Cells", "Computational Biology", "Gene Expression Regulation", "Humans", "Mesenchymal Stem Cells", "Osteogenesis", "Proteome", "Proteomics", "Transcriptome" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 0, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
9096444
Mechanism of infiltration and activation of glomerular monocytes/macrophages in IgA nephropathy.
Glomerular deposits of fibrin-related antigens (FRA), C3c, membrane attack complex (MAC) were examined by the immunoperoxidase method on 176 renal biopsy specimens from 120 cases with IgA nephropathy including 56 cases with sequential biopsies. On 47 sets of repeated renal biopsy specimens, the glomerular infiltration ...
[ 9, 3709, 1901, 20685, 18579, 2, 4480, 4784, 3, 922, 779, 4575, 1357, 35, 2084 ]
[ "Adult", "Antigens", "Biopsy", "Complement C3c", "Complement Membrane Attack Complex", "Female", "Fibrin Fibrinogen Degradation Products", "Glomerulonephritis, IGA", "Humans", "Immunoenzyme Techniques", "Kidney Glomerulus", "Macrophage Activation", "Macrophages", "Male", "Monocytes" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 0, "Z": 0 }
25176308
Nutrient release, recovery and removal from waste sludge of a biological nutrient removal system.
The uncontrolled release of nutrients from waste sludge results in nitrogen and phosphorus overloading in wastewater treatment plants when supernatant is returned to the inlet. A controlled release, recovery and removal of nutrient from the waste sludge of a Biological Nutrient Removal system (BNR) are investigated. Re...
[ 154, 8711, 49, 2572, 3518, 1480, 1243, 1071, 1660, 1825, 15991, 5685, 473, 4126, 4035, 15992, 2813, 326 ]
[ "Bacteria", "Biological Oxygen Demand Analysis", "Biopolymers", "Bioreactors", "Carbon", "Chemical Precipitation", "Crystallization", "DNA, Bacterial", "Hydrolysis", "In Situ Hybridization, Fluorescence", "Magnesium Compounds", "Nitrogen", "Phosphates", "Phosphorus", "Sewage", "Struvit...
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 1, "L": 0, "M": 0, "N": 1, "Z": 0 }
1747306
Back school for patients with vertebral fractures.
Back school is behavior training for the prevention and treatment of back problems arising from faulty body posture and muscular dysfunction. This paper describes the conception and evaluation of a back school program for patients with vertebral fractures. The curriculum includes the provision of detailed information a...
[ 204, 9, 133, 104, 5493, 5620, 1986, 2, 3, 35, 160, 970, 481, 1313, 6235, 5853, 3934 ]
[ "Adolescent", "Adult", "Aged", "Child", "Counseling", "Curriculum", "Educational Measurement", "Female", "Humans", "Male", "Middle Aged", "Patient Education as Topic", "Physical Therapy Modalities", "Posture", "Relaxation Therapy", "Schools", "Spinal Fractures" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 1, "G": 1, "H": 0, "I": 1, "J": 1, "L": 0, "M": 1, "N": 1, "Z": 0 }
7156304
Alexithymia and somatization.
Although alexithymia was originally described in patients with classical psychosomatic illnesses, attempts to specifically correlate these illnesses with alexithymia have not been successful. Despite the prominent role of somatization in the clinical description of alexithymia, a specific correlation between alexithymi...
[ 1608, 13197, 5482, 3, 963, 1927, 5257, 5232, 3461, 15340, 2940 ]
[ "Awareness", "Fantasy", "Headache", "Humans", "Mood Disorders", "Pain", "Psychological Tests", "Psychophysiologic Disorders", "Somatoform Disorders", "Spasm", "Urination Disorders" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 0, "F": 1, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
17022896
[Hidradenitis suppurativa].
BACKGROUND: Hidradenitis suppurativa is an inflammatory, chronic and recurrent disease of appocrine glands, located in inguinal, axillar, perineal, perianal areas and scalp.OBJECTIVE: To determine the frequency and therapeutic management.METHODS: A retrospective, transverse, and descriptive study was carried out. All p...
[ 9, 12, 2, 6033, 3, 35, 160, 598 ]
[ "Adult", "Cross-Sectional Studies", "Female", "Hidradenitis Suppurativa", "Humans", "Male", "Middle Aged", "Retrospective Studies" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
20143731
Assessment of haematotoxic potential of mercuric chloride in rat.
The blood is an important liquid connective tissue flow in body and performs the role of distribution of oxygen to various tissues, taken out carbon dioxide and maintains the health status of an organism. Any change in the blood components can cause adverse effects on the body. The effect of mercuric chloride has been ...
[ 30, 2744, 4478, 4138, 4447, 4111, 2, 4032, 2069, 35, 9274, 43 ]
[ "Animals", "Blood", "Blood Coagulation", "Blood Sedimentation", "Erythrocyte Count", "Erythropoiesis", "Female", "Lethal Dose 50", "Leukocyte Count", "Male", "Mercuric Chloride", "Rats" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
17079233
Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.
A number of alanine mutations in extracellular loop two (ECL2) of the thyroid-stimulating hormone receptor (TSHR) were found to increase or decrease basal activity when compared with the wild type receptor. K565A was identified as a mutant with decreased basal activity, and strongly impaired hormone induced signaling a...
[ 28, 710, 30, 4531, 3351, 197, 3, 1542, 716, 37, 4880, 666, 372, 373, 14554 ]
[ "Amino Acid Sequence", "Amino Acids", "Animals", "COS Cells", "Chlorocebus aethiops", "Flow Cytometry", "Humans", "Models, Biological", "Models, Molecular", "Molecular Sequence Data", "Mutagenesis, Site-Directed", "Mutation", "Protein Binding", "Protein Structure, Tertiary", "Receptors, ...
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
26922580
Plasma NT-proBNP is independently associated with albuminuria in type 2 diabetes.
OBJECTIVE: The aim of this study is to investigate the relationship between plasma NH2-terminal pro-brain natriuretic peptide (NT-proBNP) levels and diabetic nephropathy in type 2 diabetic patients.METHODS: The records of 983 patients with type 2 diabetes hospitalized in the Endocrinology and Metabolism Department of P...
[ 10840, 1440, 1812, 12, 1778, 1310, 9554, 2658, 2439, 2, 1779, 2702, 3, 1312, 35, 160, 8409, 717, 1274, 7976, 598, 177, 141 ]
[ "Albuminuria", "China", "Cohort Studies", "Cross-Sectional Studies", "Diabetes Mellitus, Type 2", "Diabetic Angiopathies", "Diabetic Nephropathies", "Diabetic Retinopathy", "Disease Progression", "Female", "Glycated Hemoglobin A", "Hospitals, University", "Humans", "Hypertension", "Male"...
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 1 }
1326745
Endothelin-1 stimulates chloride and potassium secretion in rabbit descending colon.
The vasoactive peptide endothelin-1 (ET-1) which is present in high concentrations in the colon, causes concentration-dependent electrogenic Cl- secretion in rabbit descending colon. This effect is half-maximal at 0.11 mumol/l. Like other secretagogues, ET-1 also stimulates K+ secretion. The secretory effect of ET-1 is...
[ 30, 3090, 2875, 2494, 4221, 34, 2076, 989, 3594, 772, 1018, 6821, 6776 ]
[ "Animals", "Chlorides", "Colon", "Dinoprostone", "Endothelins", "In Vitro Techniques", "Indomethacin", "Kidney", "Potassium", "Rabbits", "Sodium", "Sodium-Potassium-Exchanging ATPase", "Tetrodotoxin" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
9300466
Cloning of a putative voltage-gated sodium channel from the turbellarian flatworm Bdelloura candida.
The neuromuscular sodium currents of early invertebrates such as platyhelminths display distinctive kinetic and pharmacological properties. We have cloned a cDNA from the horseshoe crab flatworm Bdelloura candida that encodes a protein homologous to the primary subunit of voltage-gated sodium channels. The B. candida p...
[ 28, 30, 13302, 15678, 11344, 8335, 285, 37, 1035, 449, 43, 15679, 2155, 1304, 1146, 15680 ]
[ "Amino Acid Sequence", "Animals", "Cloning, Organism", "Decapodiformes", "Helminth Proteins", "Horseshoe Crabs", "Membrane Proteins", "Molecular Sequence Data", "Phylogeny", "Polymerase Chain Reaction", "Rats", "Scyphozoa", "Sequence Alignment", "Sequence Homology, Amino Acid", "Sodium C...
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
31012156
Synthesis and biological evaluation of novel benzo[c]acridine-diones as potential anticancer agents and tubulin polymerization inhibitors.
A new series of novel benzo[c]acridine-diones possessing pharmacophoric elements of antitubulins with central dihydropyridine bridge were designed and synthesized as potential anticancer agents and tubulin polymerization inhibitors. The cytotoxic activity of the synthesized compounds was evaluated against eight cancer ...
[ 7597, 71, 193, 1295, 389, 72, 73, 134, 1460, 2624, 10355, 3, 1911, 607, 1246, 991, 7155, 7042 ]
[ "Acridines", "Antineoplastic Agents", "Apoptosis", "Cell Cycle Checkpoints", "Cell Line, Tumor", "Cell Proliferation", "Cell Survival", "Dose-Response Relationship, Drug", "Drug Design", "Drug Screening Assays, Antitumor", "Human Umbilical Vein Endothelial Cells", "Humans", "Molecular Dockin...
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
28008962
A rapid method for detecting protein-nucleic acid interactions by protein induced fluorescence enhancement.
Many fundamental biological processes depend on intricate networks of interactions between proteins and nucleic acids and a quantitative description of these interactions is important for understanding cellular mechanisms governing DNA replication, transcription, or translation. Here we present a versatile method for r...
[ 3553, 1226, 580, 5291, 5208, 1706, 1113, 3, 4134, 8091, 1115, 4094, 372, 450, 451, 786, 1873, 1174 ]
[ "Anisotropy", "DNA", "DNA Repair", "DNA Replication", "Deoxyribonuclease BamHI", "Fluorescence", "Fluorescent Dyes", "Humans", "Ions", "Ku Autoantigen", "Microscopy, Fluorescence", "Nucleic Acids", "Protein Binding", "Protein Biosynthesis", "Proteins", "RNA", "Spectrometry, Fluoresce...
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
21571683
Dietary á-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation.
OBJECTIVE: Plant-derived á-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived n-3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown.METHODS AND RESULTS: Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2 weeks. Arterial th...
[ 30, 300, 975, 4736, 51, 867, 3119, 441, 3, 15470, 1805, 35, 36, 447, 6926, 1390, 5479, 830, 4486, 875, 14105, 1648 ]
[ "Animals", "Cardiotonic Agents", "Carotid Arteries", "Carotid Artery Thrombosis", "Cells, Cultured", "Dietary Supplements", "Endothelial Cells", "Gene Expression", "Humans", "MAP Kinase Kinase Kinase 5", "MAP Kinase Signaling System", "Male", "Mice", "Mice, Inbred C57BL", "Myocytes, Smoo...
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 1, "L": 0, "M": 0, "N": 0, "Z": 0 }
22617434
Development and validation of the Chinese version of the Massachusetts General Hospital Acupuncture Sensation Scale: an exploratory and methodological study.
BACKGROUND: The Massachusetts General Hospital Acupuncture Sensation Scale (MASS) is a tool to measure needle sensations. The aims of the present study were to develop a Chinese version and to assess its psychometric properties.METHODS: This study was a methodological and exploratory study. The English version of the M...
[ 5327, 9, 1440, 2, 930, 3, 35, 5342, 42, 10240, 2545, 1080, 12837 ]
[ "Acupuncture Therapy", "Adult", "China", "Female", "Hospitals, General", "Humans", "Male", "Massachusetts", "Pain Measurement", "Pain Perception", "Psychometrics", "Sensation", "Translating" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 1, "F": 1, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 1, "N": 1, "Z": 1 }
7320635
Effects of hypocholesterolemia and chronic hormonal stimulation on sterol and steroid metabolism in a Leydig cell tumor.
The studies presented herein were done to investigate the effects of drug-induced hypocholesterolemia and chronic hormonal stimulation on cholesterol metabolism and steroid biosynthesis in a functional Leydig cell tumor. It was found that 4-aminopyrazolo(3,4-d)-pyrimidine (4-APP)-induced hypocholesterolemia had no effe...
[ 2521, 30, 1085, 6050, 7612, 305, 9380, 35, 36, 447, 3951, 2684, 8014, 708 ]
[ "Adenine", "Animals", "Cholesterol", "Chorionic Gonadotropin", "Dyslipidemias", "Kinetics", "Leydig Cell Tumor", "Male", "Mice", "Mice, Inbred C57BL", "Neoplasms, Experimental", "Steroids", "Sterols", "Testicular Neoplasms" ]
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
1373613
Differential regulation of thyrotropin-releasing hormone receptor mRNA levels by thyroid hormone in vivo and in vitro (GH3 cells).
We studied the effect of thyroid status on thyrotropin-releasing hormone receptor (TRH-R) mRNA levels both in vivo and in vitro (GH3 cells) using a cloned rat TRH-R cDNA by RT-PCR. Experimental hypothyroid rats were produced by total thyroidectomy and were then killed 7 days after the operation. TRH receptor binding in...
[ 28, 30, 439, 1686, 657, 1225, 390, 441, 4981, 35, 37, 6059, 5456, 753, 449, 786, 452, 43, 700, 504, 14605, 3452, 2330, 3117 ]
[ "Amino Acid Sequence", "Animals", "Base Sequence", "Blotting, Northern", "Cell Line", "Cloning, Molecular", "Down-Regulation", "Gene Expression", "Hypothyroidism", "Male", "Molecular Sequence Data", "Oligodeoxyribonucleotides", "Pituitary Gland, Anterior", "Poly A", "Polymerase Chain Rea...
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
19263424
Incorporating structural characteristics for identification of protein methylation sites.
Studies over the last few years have identified protein methylation on histones and other proteins that are involved in the regulation of gene transcription. Several works have developed approaches to identify computationally the potential methylation sites on lysine and arginine. Studies of protein tertiary structure ...
[ 2376, 6241, 1703, 1541, 1855, 815, 1710, 957, 451, 1482 ]
[ "Arginine", "Asparagine", "Binding Sites", "Computer Simulation", "Glutamic Acid", "Lysine", "Methylation", "Protein Conformation", "Proteins", "Surface Properties" ]
{ "A": 0, "B": 0, "C": 0, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
27008914
Long-term prognostic significance of homocysteine in middle-aged and elderly.
OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.RESULTS: Subjects with Hcy ...
[ 133, 861, 2860, 2407, 2, 163, 5562, 3, 414, 5282, 35, 160, 397, 1814, 177 ]
[ "Aged", "Biomarkers", "Cardiovascular Diseases", "Disease-Free Survival", "Female", "Follow-Up Studies", "Homocysteine", "Humans", "Incidence", "Kaplan-Meier Estimate", "Male", "Middle Aged", "Prognosis", "Proportional Hazards Models", "Risk Factors" ]
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
25700516
Transition states. Trapping a transition state in a computationally designed protein bottle.
The fleeting lifetimes of the transition states (TSs) of chemical reactions make determination of their three-dimensional structures by diffraction methods a challenge. Here, we used packing interactions within the core of a protein to stabilize the planar TS conformation for rotation around the central carbon-carbon b...
[ 809, 7809, 602, 1541, 8907, 1277, 7548, 2898, 718, 9597, 1693, 9598 ]
[ "Alanine", "Archaeal Proteins", "Biphenyl Compounds", "Computer Simulation", "Computer-Aided Design", "Crystallography, X-Ray", "Entropy", "Models, Chemical", "Protein Structure, Secondary", "Pyrococcus abyssi", "Software", "Threonine-tRNA Ligase" ]
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
24750842
[Perinatal high-risk factors for necrotizing enterocolitis in preterm infants: a case-control study].
OBJECTIVE: To study the timing of presentation and perinatal high-risk factors for necrotizing enterocolitis (NEC) in preterm infants with a gestational age of <33 weeks.METHODS: A case-control study was conducted in 49 preterm infants with NEC (gestational age <33 weeks) who were admitted to the Neonatal Intensive Car...
[ 761, 9545, 2, 2102, 3, 229, 1485, 7749, 35, 177 ]
[ "Case-Control Studies", "Enterocolitis, Necrotizing", "Female", "Gestational Age", "Humans", "Infant, Newborn", "Infant, Premature", "Intensive Care Units, Neonatal", "Male", "Risk Factors" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
2232441
[Primaparas' perceptions of their delivery experience and their maternal-infant interactions: compared according to delivery method].
One of the important tasks for new parents, especially mothers, is to establish warm, mutually affirming interpersonal relationships with the new baby in the family, with the purpose of promoting the healthy development of the child and the wellbeing of the whole family. Nurses assess the quality of the behavioral char...
[ 3280, 3281, 2, 3, 229, 5345, 1697, 18367, 20 ]
[ "Cesarean Section", "Delivery, Obstetric", "Female", "Humans", "Infant, Newborn", "Labor, Obstetric", "Mother-Child Relations", "Obstetric Nursing", "Pregnancy" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 1, "F": 1, "G": 1, "H": 1, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
16099089
Modulation of rotational behavior in healthy volunteers by cortisol administration.
Asymmetrical turning behavior is an established indicator of asymmetrical dopaminergic activity and thought to be a manifestation of hemispatial neglect. We set out to find converging support for the hypothesis that cortisol modulates frontal dopaminergic asymmetrical activity, and hence dopaminergically mediated appro...
[ 9, 5229, 135, 6314, 2, 1925, 3, 271, 9306, 35, 160, 2370, 4693, 6942, 2373, 1737, 2825, 5334, 8186 ]
[ "Adult", "Dominance, Cerebral", "Double-Blind Method", "Exploratory Behavior", "Female", "Frontal Lobe", "Humans", "Hydrocortisone", "Individuality", "Male", "Middle Aged", "Motor Activity", "Orientation", "Perceptual Disorders", "Receptors, Dopamine D2", "Reference Values", "Sensory...
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 1, "G": 1, "H": 1, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
7159126
[Electrophysiologic effects of magnesium chloride on the Purkinje fibers of the dog].
In order to relate the cardiac antiarrhytmic properties of magnesium chloride (MgCl2) to its electrophysiological effects, a comparison of its actions on three different models of automaticity of the isolated Purkinje fibers of the dog, has been carried out. The spontaneous activity of the Purkinje fibers perfused with...
[ 30, 3087, 3088, 3089, 3090, 3091, 146, 117, 3092, 2, 3093, 732, 119, 3094, 35, 2485, 3095 ]
[ "Animals", "Anti-Arrhythmia Agents", "Barium", "Barium Compounds", "Chlorides", "Depression, Chemical", "Dogs", "Electrophysiology", "Epinephrine", "Female", "Heart Conduction System", "Heart Rate", "Magnesium", "Magnesium Chloride", "Male", "Membrane Potentials", "Purkinje Fibers" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
969572
Keratin decomposition by dermatophytes. II. Presence of s-sulfocysteine and cysteic acid in soluble decomposition products.
The dermatophyte Microsporum gypseum was grown on human hair in a mineral medium. Filtrates of cultures of various age were chromatographed on Sephadex gels and further characterized by chemical analysis and thin-layer chromatography. The products of keratin decomposition were separated into two fractions. The first fr...
[ 4310, 18767, 75, 12701, 3, 6795, 9131, 1532, 2453, 4306 ]
[ "Biodegradation, Environmental", "Cysteic Acid", "Cystine", "Hair", "Humans", "Keratins", "Microsporum", "Molecular Weight", "Peptides", "Sulfites" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 0, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 1, "Z": 0 }
11413545
Abnormal dispersion of a purkinje cell subset in the mouse mutant cerebellar deficient folia (cdf).
Purkinje cells of different molecular phenotypes subdivide the cortex of the cerebellum both rostrocaudally into parasagittal bands and mediolaterally into transverse zones. Superimposed on the Purkinje cell compartmentation, the cerebellar cortex is pleated into a reproducible array of lobes and lobules. During cerebe...
[ 30, 5511, 546, 4364, 1736, 2525, 36, 2637, 4887, 1030, 956, 17564 ]
[ "Animals", "Cell Count", "Cell Movement", "Cerebellum", "Choristoma", "Homozygote", "Mice", "Mice, Neurologic Mutants", "Morphogenesis", "Nerve Tissue Proteins", "Phenotype", "Purkinje Cells" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
26341498
Optimization of the Expression Conditions of CGA-N46 in Bacillus subtilis DB1342(p-3N46) by Response Surface Methodology.
CGA-N46 is a small antifungal-derived peptide and consists of the 31st-76th amino acids of the N-terminus of human chromogranin A. Polycistronic expression of recombinant CGA-N46 in Bacillus subtilis DB1342 was used to improve its production, but the yield of CGA-N46 was still low. In the present study, response surfac...
[ 728, 6629, 819, 13323, 2611, 3067, 9410 ]
[ "Antifungal Agents", "Bacillus subtilis", "Bacterial Proteins", "Bioengineering", "Biostatistics", "Culture Media", "Yeasts" ]
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 1, "L": 0, "M": 0, "N": 0, "Z": 0 }
19775799
Medical audit on children with asthma in an Emergency Department.
OBJECTIVE: To carry out a medical audit or evaluation and improvement procedure on the management of children with asthmatic crises in our Emergency Department (ED).MATERIAL AND METHODS: We carried out a retrospective audit between January and March 2007, analysing the medical records of a random sample of 50 patients ...
[ 204, 104, 105, 254, 1965, 7651, 3, 2703, 6228, 3288, 164, 598, 1347, 8612 ]
[ "Adolescent", "Child", "Child, Preschool", "Emergency Service, Hospital", "Guideline Adherence", "Hospitals, Pediatric", "Humans", "Medical Audit", "Medical Records", "Patient Discharge", "Practice Guidelines as Topic", "Retrospective Studies", "Spain", "Status Asthmaticus" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 1 }
24308745
Dynamics of anti-M?llerian hormone during controlled ovarian stimulation.
AIM: To evaluate the dynamics of anti-M?llerian hormone (AMH) during controlled ovarian stimulation (COH) and to correlate changes in AMH to age, estradiol (E2) levels, and the presence of polycystic ovary syndrome (PCOS).METHODS: Data were retrospectively collected from women presenting for COH in the outpatient clini...
[ 9, 7225, 765, 2, 3, 160, 2950, 598, 27 ]
[ "Adult", "Anti-Mullerian Hormone", "Estradiol", "Female", "Humans", "Middle Aged", "Ovulation Induction", "Retrospective Studies", "Young Adult" ]
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
15808265
Pattern of recurrence of trachomatous trichiasis after surgery surgical technique as an explanation.
OBJECTIVE: To evaluate the pattern of recurrence of trachomatous trichiasis (TT) after bilamellar tarsal rotation surgery for trachoma.DESIGN: Observational cohort.PARTICIPANTS: Three hundred eighty-four participants having at least 1 eye that had undergone a single TT surgery a minimum of 18 months before June 2001. T...
[ 133, 9451, 17825, 10270, 2, 558, 18228, 3, 35, 160, 10786, 695, 1237, 177, 3384, 131, 16222 ]
[ "Aged", "Chlamydia trachomatis", "Eyelashes", "Eyelid Diseases", "Female", "Functional Laterality", "Hair Diseases", "Humans", "Male", "Middle Aged", "Ophthalmologic Surgical Procedures", "Postoperative Complications", "Recurrence", "Risk Factors", "Tanzania", "Time Factors", "Tracho...
{ "A": 1, "B": 1, "C": 1, "D": 0, "E": 1, "F": 1, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 1 }
8773935
Changes in eye growth produced by drugs which affect retinal ON or OFF responses to light.
The interaction between drugs which affect ON and OFF responses to light and ocular growth was investigated in 154 eyes of newly-hatched chicks raised with normal vision or monocular occlusion with regular intravitreal injections of APB (2-amino-4 phosphonobutyric acid) or PDA (cis 2,3-piperidine-dicarboxylic acid). Th...
[ 14180, 30, 8816, 1853, 3176, 2, 426, 35, 3668, 10293, 1726, 4540 ]
[ "Aminobutyrates", "Animals", "Electroretinography", "Excitatory Amino Acid Agonists", "Eye", "Female", "Light", "Male", "Pipecolic Acids", "Refractometry", "Retina", "Vitreous Body" ]
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 1, "F": 0, "G": 1, "H": 1, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
24920210
Frequent and prolonged nocturnal occupation of port areas by Yangtze finless porpoises (Neophocaena asiaeorientalis): forced choice for feeding?
During the Yangtze Freshwater Dolphin Expedition 2012, Yangtze finless porpoises (Neophocaena asiaeorientalis) were acoustically monitored in 9 port areas at night. During 6566 min of nocturnal monitoring, porpoise sonar was detected for 488 min (7.43% of the total time). Of all 81 encounters, the longest echolocation ...
[ 30, 1440, 11332, 1719, 1379, 14133, 3970, 4477, 4594 ]
[ "Animals", "China", "Echolocation", "Ecosystem", "Feeding Behavior", "Porpoises", "Predatory Behavior", "Rivers", "Ships" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 0, "F": 1, "G": 1, "H": 0, "I": 0, "J": 1, "L": 0, "M": 0, "N": 1, "Z": 1 }
9870469
Insulin resistance precedes microalbuminuria in patients with insulin-dependent diabetes mellitus.
BACKGROUND: Insulin resistance has been associated with hypertension and with renal complications in patients with type 1 diabetes mellitus. Causal relationships have not been fully explained.METHODS: We investigated whether insulin resistance precedes microalbuminuria by measuring insulin resistance with a euglycaemic...
[ 204, 9, 10840, 104, 3635, 163, 2369, 6252, 3, 1520, 1737 ]
[ "Adolescent", "Adult", "Albuminuria", "Child", "Diabetes Mellitus, Type 1", "Follow-Up Studies", "Glucose", "Glucose Clamp Technique", "Humans", "Insulin Resistance", "Reference Values" ]
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
11177424
Neglect between but not within auditory objects.
Unilateral neglect is frequently characterized by the presence of extinction, which is a lack of awareness to contralesional visual stimuli in the presence of those further towards the ipsilesional side. It has been established that this visual extinction can be reduced if the stimuli are grouped together into a single...
[ 2928, 133, 1947, 4569, 5227, 2645, 1077, 2, 558, 3, 35, 8499, 160, 12922, 2545, 9138 ]
[ "Acoustic Stimulation", "Aged", "Attention", "Auditory Perception", "Auditory Threshold", "Cognition Disorders", "Discrimination, Psychological", "Female", "Functional Laterality", "Humans", "Male", "Memory Disorders", "Middle Aged", "Pitch Discrimination", "Psychometrics", "Sound Loca...
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 1, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 0, "Z": 0 }
2158623
The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells.
To determine the capacity of the chicken c-erbA (cTR-alpha) gene product in regulating expression of known thyroid hormone-responsive genes, both the cTR-alpha and the viral v-erbA genes were expressed in FAO cells, a rat hepatoma cell line defective for functional thyroid hormone receptors. Upon nuclear expression of ...
[ 30, 439, 2904, 194, 441, 2145, 7450, 5265, 7513, 37, 7020, 1428, 1302, 43, 10950, 5068, 6821, 3451, 1174, 3117 ]
[ "Animals", "Base Sequence", "Chickens", "Cycloheximide", "Gene Expression", "Genes", "Genomic Library", "Liver Neoplasms, Experimental", "Malate Dehydrogenase", "Molecular Sequence Data", "Phosphoenolpyruvate Carboxykinase (GTP)", "Promoter Regions, Genetic", "Proto-Oncogene Proteins", "Ra...
{ "A": 0, "B": 1, "C": 1, "D": 1, "E": 1, "F": 0, "G": 1, "H": 0, "I": 0, "J": 0, "L": 1, "M": 0, "N": 0, "Z": 0 }
16308548
[Update for the clinician].
Musculoskeletal ultrasound is of considerable value for the clinician, either if performed by himself or by the radiologist. If carried out with adequate equipments, it is an essential imaging modality and, in addition, has a definite role in clarifying the pathogenesis of different disorders and works well as a teachi...
[ 3, 890, 9444, 1100 ]
[ "Humans", "Leg", "Musculoskeletal Diseases", "Ultrasonography" ]
{ "A": 1, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 0, "N": 0, "Z": 0 }
10363298
[Neuro-cognitive condition of 8 year old children with congenital hypothyroidism treated early].
INTRODUCTION: Congenital hypothyroidism is the most important cause of preventable mental retardation. Since the use of programmes for early detection, mental retardation due to cretinism has been abolished and current investigations seek to detect subtle damage due to foetal hypothyroidism and strategies to minimize s...
[ 1402, 1937, 104, 105, 2645, 4980, 487, 2, 288, 3, 4981, 344, 35, 2329, 3116 ]
[ "Age Factors", "Brain Diseases", "Child", "Child, Preschool", "Cognition Disorders", "Congenital Hypothyroidism", "Electroencephalography", "Female", "Fetal Blood", "Humans", "Hypothyroidism", "Intelligence", "Male", "Thyrotropin", "Thyroxine" ]
{ "A": 1, "B": 1, "C": 1, "D": 1, "E": 1, "F": 1, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
18767394
[Regulation of IL-1beta and IL-8 production by mu-, delta-opiate receptors agonists in vitro].
The beta-endorphin 10(-7-)-10(-11) M in LPS (lypopolisaccharide) presence and in spontaneous cultures promoted the IL-1beta production in mixed leukocyte fraction. LPS-induced IL-8 production in leukocyte fraction was inhibited by beta-endorphin 10(-7), 10(-11) M. The enchasing effect of beta-endorphin on IL-1beta prod...
[ 9, 51, 15088, 18125, 3, 4663, 5126, 751, 1462, 2497, 35, 2085, 4271, 5819, 5821, 7073 ]
[ "Adult", "Cells, Cultured", "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-", "Enkephalin, Leucine-2-Alanine", "Humans", "Interleukin-1beta", "Interleukin-8", "Leukocytes", "Leukocytes, Mononuclear", "Lipopolysaccharides", "Male", "Neutrophils", "Oligopeptides", "Receptors, Opioid, delta", "Recepto...
{ "A": 1, "B": 1, "C": 0, "D": 1, "E": 0, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 0, "Z": 0 }
8404887
Intrauterine-neonatal torsion of the spermatic cord in an Ethiopian newborn.
The case of a neonate with scrotal swelling noted 6 hours after birth is presented. Scrotal exploration at 12 hours of age revealed a right extravaginal testicular torsion with ischemic necrosis of the testis. Intrauterine and neonatal torsion of the spermatic cord is an uncommon problem accounting for 5 to 6 percent o...
[ 3918, 2999, 3, 229, 35, 3513, 10207, 19274 ]
[ "Ethiopia", "Fetal Diseases", "Humans", "Infant, Newborn", "Male", "Necrosis", "Orchiectomy", "Spermatic Cord Torsion" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 0, "Z": 1 }
6638451
Day-case anaesthesia for termination of pregnancy. Evaluation of a total intravenous anaesthetic technique.
An investigation was undertaken to assess the use of a total intravenous anaesthetic technique of fentanyl and methohexitone for outpatient vaginal termination of pregnancy. When compared with a technique of fentanyl, methohexitone, nitrous oxide and trichloroethylene the total intravenous method caused swifter recover...
[ 6879, 204, 9, 7446, 6020, 2803, 792, 1205, 2, 2804, 3, 1666, 15742, 20, 12182 ]
[ "Abortion, Induced", "Adolescent", "Adult", "Ambulatory Surgical Procedures", "Anesthesia, General", "Anesthesia, Inhalation", "Anesthesia, Intravenous", "Evaluation Studies as Topic", "Female", "Fentanyl", "Humans", "Memory", "Methohexital", "Pregnancy", "Trichloroethylene" ]
{ "A": 0, "B": 1, "C": 0, "D": 1, "E": 1, "F": 1, "G": 1, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
24719044
Fatigue in adults with Marfan syndrome, occurrence and associations to pain and other factors.
This study aims to investigate how fatigue affects adults with verified Marfan syndrome (MFS) in their daily lives, by examining fatigue levels and prevalence of severe fatigue compared to the general Norwegian population and individuals with other comparable chronic conditions. We investigated associations between soc...
[ 474, 9, 133, 12, 4423, 2, 3, 35, 5715, 160, 1927, 1274, 13467, 483, 177, 1168, 141, 484, 27 ]
[ "Activities of Daily Living", "Adult", "Aged", "Cross-Sectional Studies", "Fatigue", "Female", "Humans", "Male", "Marfan Syndrome", "Middle Aged", "Pain", "Prevalence", "Public Health Surveillance", "Quality of Life", "Risk Factors", "Self Report", "Severity of Illness Index", "Sur...
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 1, "G": 1, "H": 0, "I": 1, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }
3451335
Minute lesions of esophageal cancer.
Fifty-four cases of minute esophageal cancer (1 cm or less in the greatest dimension) were collected and analyzed. Of these 67% were mucosal cancer and 28% were submucosal cancer. Prognosis was anticipated to be good as there was only one case of lymph node metastasis and three of vascular invasion. A lesion of 1 cm ca...
[ 9, 133, 310, 721, 1318, 3545, 2, 3, 35, 160 ]
[ "Adult", "Aged", "Aged, 80 and over", "Carcinoma, Squamous Cell", "Esophageal Neoplasms", "Esophagoscopy", "Female", "Humans", "Male", "Middle Aged" ]
{ "A": 0, "B": 1, "C": 1, "D": 0, "E": 1, "F": 0, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 0, "Z": 0 }
8558374
Late neuropsychological outcomes in preterm infants of normal IQ: selective vulnerability of the visual system.
Evaluated neuropsychological outcomes in 635 children, ages 7 to 10 years, in relation to birth weight group: < or = 1,000 g; 1,001-1,500 g; 1,501-2,500 g, and > 2,500 g. The prevalence of low IQ (< 85) was related to birth weight. Among children with IQ > 84 (N = 475): (a) Birth weight was unrelated to Verbal IQ, Perf...
[ 104, 2645, 2, 3, 8406, 229, 1485, 344, 8407, 35, 1667, 598, 2828 ]
[ "Child", "Cognition Disorders", "Female", "Humans", "Infant, Low Birth Weight", "Infant, Newborn", "Infant, Premature", "Intelligence", "Intelligence Tests", "Male", "Neuropsychological Tests", "Retrospective Studies", "Visual Perception" ]
{ "A": 0, "B": 1, "C": 0, "D": 0, "E": 1, "F": 1, "G": 0, "H": 0, "I": 0, "J": 0, "L": 0, "M": 1, "N": 1, "Z": 0 }